Introduction
It is an erosion of the gastrointestinal mucosa due to
digestive action of HCL and pepsin leading to ulceration. PUD can affect the oesophagus,
stomach and duodenum. Gastric ulcer are more common.
Types of PUD
- Acute
ulcers; this involves superficial structures.
- Chronic
ulcers this usually involves muscular structure.
Causes of PUD
- Drugs; long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve)
- Diet
- Micro-organisms; usually caused by H. pylori
- Psychological
stress
- Instrumentation
e.g. NG tube
- Genetic
factors
- Lifestyle
Pathophysiology
Peptic ulcer occurs in the gastro duodenal mucosa due to the
action of the gastric acid (HCL) and pepsin. When acid production is increased,
there is mucosal damage and the irritation of this acid to the lining of the
stomach produce gnawing and burning pain.
Clinical manifestations
- Pain
presents as gnawing burning, dull ache or severe.
- Pain may be
localized in epigastric or right hypochondriac region.
- Vomiting.
- Tenderness.
- Back pain
if posterior part of duodenum, this usually occurs 2 – 4hrs after meals.
Gastric Ulcers
- Commonly
affects lesser curvature close to antrum (other part ulcerate)
- Pain is
aggravated by hunger
- More
prevalent in women
- Usually affects
age 50-60
- Common in
low socioeconomic class and manual labourers
Duodenal Ulcer
- Accounts
80% of cases
- Associated
with high secretion of HCL acid
- 90% of
cases caused by H. Pylori
Investigations
- Endoscopy
- Barium
studies
- Liver
enzyme test
- Serum
amylase
- Full blood
count
- Stool
examination
Management
With PUD, conservative treatment are usually given.
- Rest
- Diet
modification
- Drugs
- Antacids
- H2 Antagonist
- Anti-secretory
- Anticholinergics; inhibiting the action of the
neurotransmitter acetylcholine.
- Antibiotics
- Protein pump inhibitors
- Lifestyle
modification
- Surgery
Nursing care
- Nutrition;
avoid foods that aggravate the pain e.g. pepper spicy food
- Pain
management; serve medication as ordered and educate patients to eat at regular
times
- Conserving
energy by ensuring bed rest
Indications for Surgery
- Bleeding
- Concurrent
conditions
- Multiple
spot ulcers
- Malignancy
- Obstruction
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