The use of renal replacement therapies becomes necessary when the kidneys can no longer
Remove wastes
Maintain electrolytes and regulate fluid balance.
This can occur rapidly or over a long period of time and the need for replacement therapy can be acute (short term) or chronic (long term).
The main renal replacement therapies include the various types of dialysis and kidney transplantation.
Dialysis
When a patient is in late stage chronic kidney disease (stage 4) or facing kidney failure (stage 5, end stage renal disease) he/she is referred to a dialysis and transplantation centre for kidney replacement therapy.
It is usually initiated when the patient cannot maintain a reasonable lifestyle with conservative treatment.
Types of dialysis include hemodialysis, CRRT, and Peritoneal dialysis.
Acute dialysis is indicated when there is a high and increasing level of serum potassium, fluid overload, or impending pulmonary edema, increasing acidosis, pericarditis, and severe confusion.
It may also be used to remove medications or toxins (poisoning or medication overdose) from the blood.
Chronic or maintenance dialysis is indicated in advanced CKD and ESRD in the following instances: the presence of uremic signs and symptoms affecting all body systems, hyperkalemia, fluid overload not responsive to diuretics.
The decision to initiate dialysis should be reached only after thoughtful discussion among the patient, family, physician, and others as appropriate.
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